PASSPORT

Start date: 12/2023

End date: 11/2025

The placement of these implants is sometimes accompanied by complications such as immune intolerance, infection, inflammatory reaction or incompatibility. To prevent these risks, a great deal of research is focusing on implant surface modifications. The aim is to ensure the safety, efficacy and lifespan of implants in the body. Objectives.

The aim of this project is to provide industry with innovative technical solutions in materials coating, combining biological factors to provide innovative solutions to a variety of medical problems, and to provide a differentiator for partner industries.

Neovascularization will be used in this project to demonstrate the effectiveness of this technology. One of the success factors of prosthesis integration is the ability of the host body to recolonize the implant area. Unfortunately, there are many post-operative complications, as the body does not always have the capacity to do this. The formation of new blood vessels is an important and necessary step in the survival and functionalization of the implanted medical device.

Translated with DeepL.com (free version)

Currently, in clinical practice, difficulties are encountered in colonizing implants and prostheses of different sizes, leading to post-implantation complications such as necrosis or bacterial superinfection. Some approaches focusing on the internal structuring of implants/prostheses have demonstrated a favorable impact on the development of new blood vessels. However, these results are still insufficient, particularly for large implants and in view of the patient's medical context, which justifies the use of more specific complementary solutions capable of acting directly on cell differentiation and metabolism.

The Passport project aims to study the enhancement of surface neovascularization by grafting chemical or biochemical functions using different plasma technologies.

Project partners:

CER GRoupe, Materia Nova, CMMI-ULB et CMMI-UMONS,